Title of article :
Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents
Author/Authors :
Francis Giraud، نويسنده , , Cédric Logé، نويسنده , , Fabrice Pagniez، نويسنده , , Damien Crepin، نويسنده , , Patrice Le Pape، نويسنده , , Marc Le Borgne، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A series of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols 6a–c, 7a–c, 8a, and 9a were prepared in five steps and evaluated for their antifungal activity. The most active compound 7b was docked into a home-made 3D model of the targeted enzyme confirming the importance of Tyr118, His377, and Ser378 residues in its binding mode.
Keywords :
H-bond acceptor , triazole , microwave irradiation , Azide , Candida albicans , CYP51 inhibitors , Antifungal agents , Homology model , Docking , Oxirane
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
