Author/Authors :
Stefan Peukert، نويسنده , , Yingchuan Sun، نويسنده , , Rui Zhang، نويسنده , , Brian Hurley، نويسنده , , Mike Sabio، نويسنده , , Xiaoyu Shen، نويسنده , , Christen Gray، نويسنده , , JoAnn Dzink-Fox، نويسنده , , Jianshi Tao، نويسنده , , Regina Cebula، نويسنده , , Sompong Wattanasin، نويسنده ,
Abstract :
Based on a pharmacophore hypothesis substituted tetramic and tetronic acid 3-carboxamides as well as dihydropyridin-2-one-3-carboxamides were investigated as inhibitors of undecaprenyl pyrophosphate synthase (UPPS) for use as novel antimicrobial agents. Synthesis and structure–activity relationship patterns for this class of compounds are discussed. Selectivity data and antibacterial activities for selected compounds are provided.
