Author/Authors :
Joe A. Tran، نويسنده , , Fabio C. Tucci، نويسنده , , Melissa Arellano، نويسنده , , Wanlong Jiang، نويسنده , , Caroline W. Chen، نويسنده , , Dragan Marinkovic، نويسنده , , Beth A. Fleck، نويسنده , , Jenny Wen، نويسنده , , Alan C. Foster، نويسنده , , Chen Chen، نويسنده ,
Abstract :
Based on 3-phenylpropionamides, a series of 3-arylpyrrolidine-2-carboxamide derivatives was designed and synthesized to study the effect of cyclizations as melanocortin-4 receptor ligands. It was found that the 2R,3R-pyrrolidine isomer possessed the most potent affinity among the four stereoisomers.
Keywords :
Synthesis , pyrrolidine , melanocortin-4 receptor , structure–activity relationship , Stereoisomer
