Title of article :
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents
Author/Authors :
Zhonghui Lu، نويسنده , , Gregory R. Ott، نويسنده , , Rajan Anand، نويسنده , , Ruiqin Liu، نويسنده , , Maryanne B. Covington، نويسنده , , Krishna Vaddi، نويسنده , , Mingxin Qian، نويسنده , , Robert C. Newton، نويسنده , , David D. Christ، نويسنده , , James Trzaskos، نويسنده , , James J. -W. Duan، نويسنده ,
Abstract :
Potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino hydroxamic acid scaffolds. Among them, the pyrazolopyridine provided the best overall profile when combined with tetrahydropyran β-amino hydroxamic acid scaffold. Specifically, inhibitor 49 showed IC50 value of 1 nM against porcine TACE and 170 nM in the suppression of LPS-induced TNF-α of human whole blood. Compound 49 also displayed excellent selectivity over a wide panel of MMPs as well as excellent oral bioavailability (F% > 90%) in rat n-in-1 PK studies.
