Title of article :
PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma
Author/Authors :
Nicola Antonio Colabufo، نويسنده , , Carmen Abate، نويسنده , , Marialessandra Contino، نويسنده , , Carmela Inglese، نويسنده , , Mauro Niso، نويسنده , , Francesco Berardi، نويسنده , , Roberto Perrone، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
PB183, a non-selective sigma receptor ligand displaying high sigma-1 and sigma-2 receptor affinity, was evaluated in prostate tumour cell lines for its suitability as PET radiotracer. The pharmacodynamic and pharmacokinetic properties suggested PB183 as a potential PET radiotracer to visualize prostate adenocarcinoma.
Keywords :
PET , Cyclohexylpiperazine derivative , PB28 , TRAMP cells , prostate adenocarcinoma , PB183
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
