Title of article
Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles
Author/Authors
Bertrand Le Bourdonnec، نويسنده , , William M. Barker، نويسنده , , Serge Belanger، نويسنده , , Daniel D. Wiant، نويسنده , , Nathalie C. Conway-James، نويسنده , , Joel A. Cassel، نويسنده , , Timothy J. O’Neill، نويسنده , , Patrick J. Little، نويسنده , , Robert N. DeHaven، نويسنده , , Diane L. DeHaven-Hudkins، نويسنده , , Roland E. Dolle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
2006
To page
2012
Abstract
A series of N-substituted trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines, μ opioid receptor antagonists, analogs of alvimopan, were prepared using solid phase methodology. This study led to the identification of a highly selective μ opioid receptor antagonist, which interacts selectively with μ peripheral receptors.
Keywords
solid phase synthesis , ? receptors , Opioid
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799289
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