Title of article
Synthesis and biological evaluation of PEG-tirofiban conjugates
Author/Authors
Laurent Désaubry، نويسنده , , Stéphanie Riché، نويسنده , , Patricia Laeuffer، نويسنده , , Jean-Pierre Cazenave، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2028
To page
2031
Abstract
We have conjugated tirofiban, an antagonist of the GPIIb/IIIa integrin receptor, to PEG, and shown that these polymers effectively inhibit platelet aggregation. This inhibition decreased with the size of the polymer. Our goal was to develop new cryoprotective agents to store frozen platelets. Surprisingly, tirofiban-conjugated PEG did not exhibit any protection.
Keywords
PEG , Cryopreservation , platelet aggregation , GPIIb/IIIa receptor , antithrombotic , Poly(ethylene glycol)
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799293
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