Author/Authors :
Michael J. Morytko، نويسنده , , Patrick Betschmann، نويسنده , , Kevin Woller، نويسنده , , Anna Ericsson، نويسنده , , Haipeng Chen، نويسنده , , Diana L. Donnelly-Roberts، نويسنده , , Marian T. Namovic، نويسنده , , Michael F. Jarvis، نويسنده , , William A. Carroll، نويسنده , , Paul Rafferty، نويسنده ,
Abstract :
A novel series of cyanoguanidine-piperazine P2X7 antagonists was designed based upon the structure of A-740003. Structure–activity relationship (SAR) studies focused on the piperazine moiety and the right hand side substitution. Compounds were assayed for activity at human and rat P2X7 receptors and compound 29 was found to possess potent activity (IC50 = 30–60 nM) at both species.
Keywords :
P2X7 , Antagonist , Cyanoguanidine , piperazine
