Title of article :
Photochemical DNA cleavage by novel water-soluble sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole
Author/Authors :
Lei Huang، نويسنده , , Cheng Zhong، نويسنده , , Fushi Zhang، نويسنده , , Chen-Ho Tung، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The photosensitizing properties of a novel water-soluble phthalocyanine-like photosensitizer, sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole {P(OH)2TBCSn}, have been reported. It is relevant for the use of this dye as photodynamic sensitizer. The compound exhibited significant photocleavage of supercoiled (SC) pUC19 DNA. The photooxygenation and photocleavage to DNA showed high efficiency in generating singlet oxygen.
Keywords :
Tetrabenzotriazacorrole , Phosphorus , DNA , cleavage
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
