Title of article :
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)
Author/Authors :
Xenia Beebe، نويسنده , , Daria Darczak، نويسنده , , Rachel A. Davis-Taber، نويسنده , , Marie E. Uchic، نويسنده , , Victoria E. Scott، نويسنده , , Michael F. Jarvis، نويسنده , , Andrew O. Stewart، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Potent small molecule antagonists for the PAC1-R have been discovered. Previously known antagonists for the PAC1-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.
Keywords :
PACAP , Class B GPCR , Hydrazides , PAC1-R
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
