Title of article
Discovery and SAR of hydrazide antagonists of the pituitary adenylate cyclase-activating polypeptide (PACAP) receptor type 1 (PAC1-R)
Author/Authors
Xenia Beebe، نويسنده , , Daria Darczak، نويسنده , , Rachel A. Davis-Taber، نويسنده , , Marie E. Uchic، نويسنده , , Victoria E. Scott، نويسنده , , Michael F. Jarvis، نويسنده , , Andrew O. Stewart، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2162
To page
2166
Abstract
Potent small molecule antagonists for the PAC1-R have been discovered. Previously known antagonists for the PAC1-R were slightly truncated peptide ligands. The hydrazides reported here are the first small molecule antagonists ever reported for this class B GPCR.
Keywords
PACAP , Class B GPCR , Hydrazides , PAC1-R
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799317
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