Title of article
Pharmacophore identification of Raf-1 kinase inhibitors
Author/Authors
Tian Zhu، نويسنده , , Yu Jiao، نويسنده , , Yadong Chen ، نويسنده , , Xuan Wang، نويسنده , , Hui-Fang Li، نويسنده , , Luyong Zhang، نويسنده , , Jian Tao Lü، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2346
To page
2350
Abstract
A three-dimensional pharmacophore model was developed based on 25 currently available Raf-1 kinase inhibitors. The best pharmacophore hypothesis (Hypo1), consisting of four chemical features (one hydrogen-bond acceptor, one hydrogen-bond donor, and two hydrophobic groups), has a correlation coefficient of 0.972. The results of our study provide a valuable tool in designing new leads with desired biological activity by virtual screening.
Keywords
Pharmacophore , Docking , Homology modeling , Raf-1 kinase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799357
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