Title of article
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors
Author/Authors
Manas K. Haldar، نويسنده , , MICHAEL D. SCOTT، نويسنده , , Nitesh Sule، نويسنده , , D.K. Srivastava، نويسنده , , Sanku Mallik، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2373
To page
2376
Abstract
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
Keywords
Type-1 MetAP inhibitors , Barbiturates
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799362
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