Title of article :
Synthesis of barbiturate-based methionine aminopeptidase-1 inhibitors
Author/Authors :
Manas K. Haldar، نويسنده , , MICHAEL D. SCOTT، نويسنده , , Nitesh Sule، نويسنده , , D.K. Srivastava، نويسنده , , Sanku Mallik، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The syntheses of a new class of barbiturate-based inhibitors for human and Escherichia Coli methionine aminopeptidase-1 (MetAP-1) are described. Some of the synthesized inhibitors show selective inhibition of the human enzyme with high potency.
Keywords :
Type-1 MetAP inhibitors , Barbiturates
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
