Title of article :
Lead identification of 2-iminobenzimidazole antagonists of the chemokine receptor CXCR3
Author/Authors :
Martin E. Hayes، نويسنده , , Eric C. Breinlinger، نويسنده , , Grier A. Wallace، نويسنده , , Pintipa Grongsaard، نويسنده , , Wenyan Miao، نويسنده , , Michael J. McPherson، نويسنده , , Robert H. Stoffel، نويسنده , , David W. Green، نويسنده , , Gregory P. Roth، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Modification of a 2-iminobenzimidazole series derived from an HTS hit resulted in compounds with improved in-vitro species selectivity. Incorporation of an 8-quinoline amide and conformational rigidification of an aliphatic tether furnished potent compounds suitable for further lead optimization.
Keywords :
IP-10 , CXCL10 , Multiple sclerosis , 2-Iminobenzimidazole , Chemokine , Chemokine antagonist , CXCR3 , Benzimidazole
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
