Title of article :
Synthesis and anti-protozoal activity of C2-substituted polyazamacrocycles
Author/Authors :
Caroline M. Reid، نويسنده , , Charles Ebikeme، نويسنده , , MICHAEL P. BARRETT، نويسنده , , Eva-Maria Patzewitz، نويسنده , , Sylke Müller، نويسنده , , David J. Robins، نويسنده , , Andrew Sutherland، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
A focused library of C2-substituted-1,4,7,10-tetraazacyclododecanes was synthesised and the compounds were tested for their ability to kill trypanosome and malaria parasites. Several compounds showed significant in vitro activity and were selectively active against the parasites over human embryonic kidney cells used as a counter screen.
Keywords :
Macrocycles , malaria , Anti-protozoal , Trypanosomes
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
