Title of article :
Fluorination of triptolide and its analogues and their cytotoxicity
Author/Authors :
Yutaka Aoyagi، نويسنده , , Yukio Hitotsuyanagi، نويسنده , , Tomoyo Hasuda، نويسنده , , Saki Matsuyama، نويسنده , , Haruhiko Fukaya، نويسنده , , Koichi Takeya، نويسنده , , Ritsuo Aiyama، نويسنده , , Takeshi Matsuzaki، نويسنده , , Shusuke Hashimoto، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The reaction of triptolide and its analogues with a fluorinating agent, that is, bis(2-methoxyethyl)aminosulfur trifluoride (Deoxo-Fluor) or (diethylamino)sulfur trifluoride (DAST), was studied. One of the fluorinated products, 14β-dehydroxy-14β-fluoro triptolide, was found to be more cytotoxic than the parent natural triptolide.
Keywords :
Triptolide , SAR , Tripterygium wilfordii , Fluorination , Semisynthesis , cytotoxicity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
