Author/Authors :
Naoki Teno، نويسنده , , Osamu Irie، نويسنده , , Takahiro Miyake، نويسنده , , Keigo Gohda، نويسنده , , Miyuki Horiuchi، نويسنده , , Sachiyo Tada، نويسنده , , Kazuhiko Nonomura، نويسنده , , Motohiko Kometani، نويسنده , , Genji Iwasaki، نويسنده , , Claudia Betschart، نويسنده ,
Abstract :
Cyano pyrimidine acetylene and cyano pyrimidine t-amine, which belong to a new chemical class, were prepared and tested for inhibitory activities against cathepsin K and the highly homologous cathepsins L and S. The use of novel chemotypes in the development of cathepsin K inhibitors has been demonstrated by derivatives of compounds 1 and 8.
Keywords :
Non-peptidic inhibitors , Cathepsin K , New chemotype , Cyano pyrimidine t-amine , Cyano pryrimidine acetylene
