Synthesis of 4′-modified noraristeromycins to clarify the effect of the 4′-hydroxyl groups for inhibitory activity against S-adenosyl-l-homocysteine hydrolase

4′-Modified noraristeromycin (NAM) analogs, 4′-sulfo-, 4′-sulfamoy, 4′-azido and 4′-amino-NAM, were systematically synthesized. The inhibitory activities of these analogs and related compounds against Plasmodium falciparum and human S-adenosyl-l-homocysteine hydrolase were investigated.