Title of article
Novel bisbenzimidazoles with antileishmanial effectiveness
Author/Authors
Annie Mayence، نويسنده , , Aurélie Pietka، نويسنده , , Margaret S. Collins، نويسنده , , Melanie T. Cushion، نويسنده , , Babu L. Tekwani، نويسنده , , Tien L. Huang، نويسنده , , Jean Jacques Vanden Eynde، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2658
To page
2661
Abstract
A small library of 2,2′-[(α,ω-alkanediylbis(oxyphenylene)]bis-1H-benzimidazoles has been prepared and screened in vitro against Pneumocystis carinii, Trypanosoma brucei rhodesiense, and Leishmania donovani. Among the six tested compounds two derivatives emerged as promising hits characterized by IC50 values lower than that determined for pentamidine against L. donovani.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799425
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