Title of article :
Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines
Author/Authors :
Catherine Bardelle، نويسنده , , Darren Cross، نويسنده , , Sara Davenport، نويسنده , , Jason G. Kettle، نويسنده , , Eun Jung Ko، نويسنده , , Andrew G. Leach، نويسنده , , Andrew Mortlock، نويسنده , , Jon Read، نويسنده , , Nicola J. Roberts، نويسنده , , Peter Robins، نويسنده , , Emma J. Williams، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
2776
To page :
2780
Abstract :
A series of bis-anilinopyrimidines have been identified as potent inhibitors of the tyrosine kinase EphB4. Structural information from two alternative series identified from screening efforts was combined to identify the initial leads.
Keywords :
EphB4 , kinase , structure-based design , Lead identification
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799445
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799445
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