Title of article
New tetrazole-based selective anandamide uptake inhibitors
Author/Authors
Giorgio Ortar، نويسنده , , Aniello Schiano Moriello، نويسنده , , Maria Grazia Cascio، نويسنده , , Luciano De Petrocellis، نويسنده , , Alessia Ligresti، نويسنده , , Enrico Morera، نويسنده , , Marianna Nalli، نويسنده , , Vincenzo Di Marzo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2820
To page
2824
Abstract
A new series of 1,5- and 2,5-disubstituted tetrazoles have been synthesized and evaluated as inhibitors of anandamide cellular uptake. Some of them inhibit the uptake process with a relatively high potency (IC50 = 2.3–5.1 μM) and selectively over other proteins involved in endocannabinoid action and metabolism.
Keywords
Anandamide uptake , Endocannabinoids , Tetrazoles , anandamide uptake inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799453
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