Title of article :
Dual binding site inhibitors of B-RAF kinase
Author/Authors :
Ronald L. Wolin، نويسنده , , Scott D. Bembenek، نويسنده , , Jianmei Wei، نويسنده , , Shelby Crawford، نويسنده , , Katherine Lundeen، نويسنده , , Anders Brunmark، نويسنده , , Lars Karlsson، نويسنده , , James P. Edwards، نويسنده , , Jonathan M. Blevitt، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
5
From page :
2825
To page :
2829
Abstract :
Computer aided modeling guided the design of a series of diarylimidazole compounds (11–22) intended to interact with both the ATP and adjacent allosteric binding domains of B-RAF kinase. Their ability to inhibit the function of B-RAF kinase and intracellular ERK1/2 phosphorylation were evaluated.
Keywords :
B-Raf , Kinase inhibitors , Diarylimidazoles
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2008
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
799454
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=799454
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