Title of article
Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase
Author/Authors
Yuli Xie، نويسنده , , Yidong Liu، نويسنده , , Gangli Gong، نويسنده , , Alison Rinderspacher، نويسنده , , Shixian Deng، نويسنده , , Deborah H. Smith، نويسنده , , Udo Toebben، نويسنده , , Effie Tzilianos، نويسنده , , Lars Branden، نويسنده , , Du?ica Vidovi?، نويسنده , , Caty Chung، نويسنده , , Stephan Schürer، نويسنده , , Lutz Tautz، نويسنده , , Donald W. Landry، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2840
To page
2844
Abstract
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.
Keywords
Thiazolidine , Lyp , pTyr mimics , Salicylate
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799457
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