Title of article
Novel echinocandin antifungals. Part 2: Optimization of the side chain of the natural product FR901379. Discovery of micafungin
Author/Authors
Masaki Tomishima، نويسنده , , Hidenori Ohki، نويسنده , , Akira Yamada، نويسنده , , Katsuyuki Maki، نويسنده , , Fumiaki Ikeda، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
2886
To page
2890
Abstract
Further optimization of the potent antifungal activity of side chain analogs of the natural product FR901379 led to the discovery of compound 8 with an excellent, well-balanced profile. Potent compounds with reduced hemolytic potential were designed based upon a disruption of the linearity of the terphenyl lipophilic side chain. The optimized compound (8, FK463, micafungin) displayed the best balance and was selected as the clinical candidate.
Keywords
Antifungal , natural product , FR901379 , FR13153 , FK463 , Micafungin , Echinocandin , Candida albicans , Aspergillus fumigatus , Isoxazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799466
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