Author/Authors :
Heuisul Park، نويسنده , , Kyeongsik Min، نويسنده , , Hyo Shin Kwak، نويسنده , , Ki Dong Koo، نويسنده , , Dongchul Lim، نويسنده , , Sang-Won Seo، نويسنده , , Jae-Ung Choi، نويسنده , , Bettina Platt، نويسنده , , Deog-Young Choi، نويسنده ,
Abstract :
We describe synthesis and evaluation of a series of cyclic urea derivatives with hydroxylethylamine isostere. Modification of P3, P1, and P2′ and combination of SAR display a >100-fold increase in potency with good cellular activity (IC50 = 0.15 μM) relative to the previously reported compound 3.
