Title of article
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds
Author/Authors
Pierre Ducray، نويسنده , , Noëlle Gauvry، نويسنده , , François Pautrat، نويسنده , , Thomas Goebel، نويسنده , , Joerg Fruechtel، نويسنده , , Yves Desaules، نويسنده , , Sandra Schorderet Weber، نويسنده , , Jacques Bouvier، نويسنده , , Trixie Wagner، نويسنده , , Olivier Froelich، نويسنده , , Ronald Kaminsky، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
2935
To page
2938
Abstract
A new series of amino-acetonitrile derivatives (AAD) have been discovered that exhibit high anthelmintic activity against parasitic nematode species such as Haemonchus contortus and Trichostrongylus colubriformis. Significantly, these compounds also demonstrate activity against nematode strains resistant to the currently available broad-spectrum anthelmintics. The discovery, synthesis, structure–activity relationship and biological results are presented.
Keywords
Haemonchus contortus , Amino-acetonitrile derivatives , AAD , anthelmintic , Parasiticide , Nematocide
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799476
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