Title of article
Facile synthesis of substituted trans-2-arylcyclopropylamine inhibitors of the human histone demethylase LSD1 and monoamine oxidases A and B
Author/Authors
David M. Gooden، نويسنده , , Dawn M.Z. Schmidt، نويسنده , , Julie A. Pollock، نويسنده , , Ami M. Kabadi، نويسنده , , Dewey G. McCafferty، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3047
To page
3051
Abstract
A facile synthetic route to substituted trans-2-arylcyclopropylamines was developed to provide access to mechanism-based inhibitors of the human flavoenzyme oxidase lysine-specific histone demethylase LSD1 and related enzyme family members such as monoamine oxidases A and B.
Keywords
Enaminonitrile , Quinozoline , Horner–Wadsworth–Emmons , Cell-based assays
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799500
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