Title of article
Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
Author/Authors
Mark T. Bilodeau، نويسنده , , Adrienne E. Balitza، نويسنده , , Jacob M. Hoffman، نويسنده , , Peter J. Manley، نويسنده , , Stanley F. Barnett، نويسنده , , Deborah Defeo-Jones، نويسنده , , Kathleen Haskell، نويسنده , , Raymond E. Jones، نويسنده , , Karen Leander، نويسنده , , Ronald G. Robinson، نويسنده , , Anthony M. Smith، نويسنده , , Hans E. Huber، نويسنده , , George D. Hartman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3178
To page
3182
Abstract
A series of naphthyridine and naphthyridinone allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been optimized to have potent dual activity against the activated kinase as well as the activation of Akt in cells. One molecule in particular, compound 17, has potent inhibitory activity against Akt1 and 2 in vivo in a mouse lung and efficacy in a tumor xenograft model.
Keywords
Akt , Oncology
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799525
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