Author/Authors :
Ping Liu، نويسنده , , Shaolong Zhu، نويسنده , , Peng Li، نويسنده , , Weijie Xie، نويسنده , , Yongsheng Jin، نويسنده , , Qingyan Sun، نويسنده , , Qiuye Wu، نويسنده , , Peng Sun، نويسنده , , Yingjun Zhang، نويسنده , , Xiaohong Yang، نويسنده , , Yuanying Jiang، نويسنده , , Dazhi Zhang، نويسنده ,
Abstract :
A series of 1-(substituted biaryloxy)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol were synthesized and their antifungal activities were evaluated against eight human pathogenic fungi in vitro. Seventeen compounds showed activity 4- to 64-fold higher than voriconazole against Candida albicans. SAR clearly suggested that introduction of a biaryloxy side chain greatly enhanced the antifungal activity of triazole analogs against Candida species.
