Title of article
Designing better coumarin-based fluorogenic substrates for PTP1B
Author/Authors
Christopher P. Holmes، نويسنده , , Natalie Macher، نويسنده , , J. Russell Grove، نويسنده , , Larry Jang، نويسنده , , Jennifer D. Irvine، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
3382
To page
3385
Abstract
As part of a program to develop better PTP1B fluorogenic substrates that more closely mimic the functionality found in the natural substrate, we have prepared and evaluated nine novel analogs of 4-methylumbelliferone phosphate (MUP) with a variety of additional groups occupying the second phosphate binding pocket.
Keywords
PTP1B , Substrate , Fluorogenic , coumarin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799565
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