Author/Authors :
Yuping Zhu، نويسنده , , Steven H. Olson، نويسنده , , Anne Hermanowski-Vosatka، نويسنده , , Steven Mundt، نويسنده , , Kashmira Shah، نويسنده , , Marty Springer، نويسنده , , Rolf Thieringer، نويسنده , , Samuel Wright، نويسنده , , Jianying Xiao، نويسنده , , Hratch Zokian، نويسنده , , James M. Balkovec، نويسنده ,
Abstract :
4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.
