Title of article
4-Methyl-5-phenyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Author/Authors
Yuping Zhu، نويسنده , , Steven H. Olson، نويسنده , , Anne Hermanowski-Vosatka، نويسنده , , Steven Mundt، نويسنده , , Kashmira Shah، نويسنده , , Marty Springer، نويسنده , , Rolf Thieringer، نويسنده , , Samuel Wright، نويسنده , , Jianying Xiao، نويسنده , , Hratch Zokian، نويسنده , , James M. Balkovec، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
3405
To page
3411
Abstract
4-Methyl-5-phenyl-(1,2,4)-triazoles were identified as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). They were active in vitro and in an in vivo mouse pharmacodynamic (PD) model. The synthesis and structure activity relationships are presented.
Keywords
11?-HSD1 , metabolic syndrome , 4-Methyl-5-phenyl triazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799569
Link To Document