Author/Authors :
Suresh K. Tipparaju، نويسنده , , Sipak Joyasawal، نويسنده , , Sara Forrester، نويسنده , , Debbie C. Mulhearn، نويسنده , , Scott Pegan، نويسنده , , Michael E. Johnson، نويسنده , , Andrew D. Mesecar، نويسنده , , Alan P. Kozikowski، نويسنده ,
Abstract :
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
