Title of article :
C3-Spacer-containing circular oligonucleotides as inhibitors of human topoisomerase I
Author/Authors :
Yifan Wang، نويسنده , , Magdeline Tao Tao Ng، نويسنده , , Tianyan Zhou، نويسنده , , Xinming Li، نويسنده , , Choon Hong Tan، نويسنده , , Tianhu Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Some dumbbell-shaped circular oligonucleotides containing internal C3-spacers and Topo I-binding sites were designed and synthesized which displayed high inhibitory efficiency on the activity of human Topo I as well as resisted the degradation by some DNA repair enzymes.
Keywords :
Circular oligonucleotide , Human topoisomerase I , Enzyme inhibitor
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
