Author/Authors :
Manoj V. Lohar، نويسنده , , Ramswaroop Mundada، نويسنده , , Mandar Bhonde، نويسنده , , Amol Padgaonkar، نويسنده , , Vijaykumar Deore، نويسنده , , Nilambari Yewalkar، نويسنده , , Dimple Bhatia، نويسنده , , Maggie Rathos، نويسنده , , Kalpana Joshi and Bhushan Patwardhan ، نويسنده , , Ram A. Vishwakarma، نويسنده , , Sanjay Kumar، نويسنده ,
Abstract :
We herein report the design and synthesis of furoquinoline based novel molecules (16–36) and their in vitro multiple targeted inhibitory potency against PI3K/Akt phosphorylation and mTOR using cell based and cell-free kinase assay. In particular, compound 23 in addition to PI3K-mTOR inhibitory potency, it has shown potent inhibition of hypoxia-induced accumulation of HIF-1α protein in U251-HRE cell line. The inhibitory activities of compound 23 were confirmed by Western blot analysis, using human non-small cell lung carcinoma H-460 cell line and glioblastoma U251 cell lines.
