Title of article
Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design
Author/Authors
Gui-Bai Liang، نويسنده , , Xiaoxia Qian، نويسنده , , Tesfaye Biftu، نويسنده , , Suresh Singh، نويسنده , , Yingduo Gao، نويسنده , , Giovanna Scapin، نويسنده , , Sangita Patel، نويسنده , , Barbara Leiting، نويسنده , , Reshma Patel، نويسنده , , Joseph Wu، نويسنده , , Xiaoping Zhang، نويسنده , , Nancy A. Thornberry، نويسنده , , Ann E. Weber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3706
To page
3710
Abstract
Probing with tool molecules, and by modeling and X-ray crystallography the binding modes of two structurally distinct series of DPP-4 inhibitors led to the discovery of a rare aromatic fluorine H-bond and the spatial requirement for better biaryl binding in the DPP-4 enzyme active site. These newly found binding elements were successfully incorporated into novel DPP-4 inhibitors.
Keywords
diabetes , DPP-4 inhibitors , Fluorine H-bond
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799637
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