Title of article :
Fungicidal activity of truncated analogues of dihydrosphingosine
Author/Authors :
Karin Thevissen، نويسنده , , Ulrik Hillaert، نويسنده , , Els M.K. Meert، نويسنده , , Kuen K. Chow، نويسنده , , Bruno PA Cammue، نويسنده , , Serge Van Calenbergh، نويسنده , , Isabelle E.J.A. François، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The minimal fungicidal concentration (MFC) of dihydrosphingosine (DHS), phytosphingosine (PHS), and five short-chain DHS derivatives was determined for Candida albicans and Candida glabrata. In this respect, a C15- and a C17-homologue of DHS showed a 2- to 10-fold decreased MFC as compared to native DHS (i.e. C18-DHS). DHS derivatives that were active, that is, comprising 12, 15, 17, or 18 carbon atoms, induced accumulation of reactive oxygen species (ROS) in C. albicans.
Keywords :
Sphingoid base , Dihydrosphingosine , fungicidal , Candida albicans , Candida glabrata , reactive oxygen species
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
