Title of article :
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum
Author/Authors :
Nicola Antonio Colabufo، نويسنده , , Francesco Berardi، نويسنده , , Marialessandra Contino، نويسنده , , Carmela Inglese، نويسنده , , Mauro Niso، نويسنده , , Roberto Perrone، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Several reference compounds such as Cyclosporin A, Tamoxifen, Verapamil, and our compound 1, known as P-gp modulators, have been tested for their P-gp modulating activity in isolated organ bath. Compound 1 showed the best result in organ bath experiment (EC50 = 14.7 μM), Cyclosporin A and Tamoxifen displayed EC50 = 25.2 and 39.4 μM, respectively.
Keywords :
Rhodamine-123 , Guinea-Pig ileum , P-glycoprotein
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
