Author/Authors :
Shiori Oshimi، نويسنده , , Yuichiro Tomizawa، نويسنده , , Yusuke Hirasawa، نويسنده , , Toshio Honda، نويسنده , , Wiwied Ekasari، نويسنده , , Aty Widyawaruyanti، نويسنده , , Marcellino Rudyanto، نويسنده , , Gunawan Indrayanto، نويسنده , , Noor Cholies Zaini، نويسنده , , Hiroshi Morita، نويسنده ,
Abstract :
A new bischromone, chrobisiamone A (1) with an antiplasmodial activity has been isolated from the leaves of Cassia siamea and the structure was elucidated by 2D NMR analysis. Cyclization of 5-acetonyl-7-hydroxy-2-methylchromone (2) in the presence of ammonium acetate resulted in generation of cassiarin A (3) with an unprecedented tricyclic skeleton, supporting a biogenetic pathway proposed for 3.
Keywords :
Chrobisiamone A , Bischromone , Antiplasmodial activity , Biomimetic transformation , Cassia siamea
