Title of article :
Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida
Author/Authors :
Yosuke Matsuno، نويسنده , , Jun Deguchi، نويسنده , , Yusuke Hirasawa، نويسنده , , Kunio Ohyama، نويسنده , , Hiroo Toyoda، نويسنده , , Chieko Hirobe، نويسنده , , Wiwied Ekasari، نويسنده , , Aty Widyawaruyanti، نويسنده , , Noor Cholies Zaini، نويسنده , , Hiroshi Morita، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Two new cassane-type diterpenes, sucutiniranes A (1) and B (2), have been isolated from the seeds of Bowdichia nitida together with 6α-acetoxyvouacapane (3) and 6α,7β-diacetoxyvouacapane (4), and the structures of 1 and 2 were elucidated by using 2D NMR data and chemical correlations. Sucutinirane A (1) and 3 showed a moderate cytotoxicity against human colon carcinoma COLO201 cells, and 6α,7β-diacetoxyvouacapane (4) showed in vitro antiplasmodial activity against parasite Plasmodium falciparum 3D7.
Keywords :
Diterpene , Sucutinirane A , Sucutinirane B , Bowdichia nitida , Antiplasmodial activity , cytotoxicity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
