Title of article
4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors
Author/Authors
Paola Pace، نويسنده , , Stéphane A.H. Spieser، نويسنده , , Vincenzo Summa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
3865
To page
3869
Abstract
The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress™, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors.
Keywords
Diketoacids , pyrimidines , AIDS , HIV-1 integrase , Pyrrolinones
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799670
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