Title of article
Discovery of novel and potent aryl diamines as leukotriene A4 hydrolase inhibitors
Author/Authors
Seock-Kyu Khim، نويسنده , , John Bauman، نويسنده , , Jarred Evans، نويسنده , , Beverly Freeman، نويسنده , , Beverly King، نويسنده , , Thomas Kirkland، نويسنده , , Monica Kochanny، نويسنده , , Dao Lentz، نويسنده , , Amy Liang، نويسنده , , Lisa Mendoza، نويسنده , , Gary Phillips، نويسنده , , Jih-Lie Tseng، نويسنده , , Robert G. Wei، نويسنده , , Hong Ye، نويسنده , , Limei Yu، نويسنده , , John Parkinson، نويسنده , , William J. Guilford، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
3895
To page
3898
Abstract
The synthesis and biological evaluation of a series of aryl diamines as inhibitors of LTA4-h inhibitors are described. The optimization which led to the identification of the optimal para-substitution on the diphenyl ether moiety and diamine spacer is discussed. The resulting compounds such as 3l have excellent enzyme and cellular potency as well as desirable pharmacokinetic properties.
Keywords
Antiinflammatory , Leukotriene A4 , LTA4 , Enzyme inhibitor , leukotriene A4 hydrolase
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799677
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