Title of article
T-type Ca2+ channel blockers suppress the growth of human cancer cells
Author/Authors
Jae Ho Heo، نويسنده , , Han Na Seo، نويسنده , , Yun Jeong Choe، نويسنده , , Sujin Kim، نويسنده , , Chun Rim Oh، نويسنده , , Young Deuk Kim، نويسنده , , Hyewhon Rhim، نويسنده , , Dong Joon Choo، نويسنده , , Jungahn Kim، نويسنده , , Jae Yeol Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
3
From page
3899
To page
3901
Abstract
In order to further clarify the role of T-type Ca2+ channels in cell proliferation, we have measured the growth inhibition of human cancer cells by using our potent T-type Ca2+ channel blockers. As a result, KYS05090, a most potent T-type Ca2+ channel blocker, was found to be as potent as doxorubicin against some human cancer cells without acute toxicity. Therefore, this letter provides the biological results that T-type calcium channel is important in regulating the important cellular phenotype transition leading to cell proliferation, and thus novel T-type Ca2+ channel blocker presents new prospects for cancer treatment.
Keywords
3 , 4-Dihydroquinazoline , Anti-cancer , T-type calcium channel blocker , doxorubicin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799678
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