Title of article :
Gallic acid-based indanone derivatives as anticancer agents
Author/Authors :
Hari Om Saxena، نويسنده , , Uzma Faridi، نويسنده , , Suchita Srivastava، نويسنده , , J.K. Kumar، نويسنده , , M.P. Darokar، نويسنده , , Suaib Luqman، نويسنده , , C.S. Chanotiya، نويسنده , , Vinay Krishna، نويسنده , , Arvind S. Negi، نويسنده , , S.P.S. Khanuja، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Gallic acid-based indanone derivatives have been synthesised. Some of the indanones showed very good anticancer activity in MTT assay. Compounds 10, 11, 12 and 14 possessed potent anticancer activity against various human cancer cell lines. The most potent indanone (10, IC50 = 2.2 μM), against MCF-7, that is, hormone-dependent breast cancer cell line, showed no toxicity to human erythrocytes even at higher concentrations (100 μg/ml, 258 μM). While, indanones 11, 12 and 14 showed toxicities to erythrocytes at higher concentrations.
Keywords :
Gallic acid , Indanones , anticancer , osmotic fragility , HMQC
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
