Author/Authors :
Samir Ghosh، نويسنده , , Pallavi Tiwari، نويسنده , , Shashi Pandey، نويسنده , , Anup Kumar Misra، نويسنده , , Vinita Chaturvedi، نويسنده , , Anil Gaikwad، نويسنده , , Shalini Bhatnagar، نويسنده , , Sudhir Sinha، نويسنده ,
Abstract :
A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H37Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 μg/mL, 6 compounds at MIC of 3.125 μg/mL and 1 compound at MIC of 1.56 μg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.
