Title of article
Discovery of new Gram-negative antivirulence drugs: Structure and properties of novel E. coli WaaC inhibitors
Author/Authors
F. Moreau، نويسنده , , N. Desroy، نويسنده , , J.M. Genevard، نويسنده , , V. Vongsouthi، نويسنده , , V. Gerusz، نويسنده , , G. Le Fralliec، نويسنده , , C. Oliveira، نويسنده , , S. Floquet، نويسنده , , A. Denis، نويسنده , , S. Escaich، نويسنده , , K. Wolf، نويسنده , , M. Busemann، نويسنده , , A. Aschenbrenner، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4022
To page
4026
Abstract
Heptosyltransferases such as WaaC represent promising and attractive targets for the discovery of new Gram-negative antibacterial drugs based on antivirulence mechanisms. We report herein our approach to the identification of the first micromolar inhibitors of WaaC and the preliminary SAR generated from this family of 2-aryl-5-methyl-4-(5-aryl-furan-2-yl-methylene)-2,4-dihydro-pyrazol-3-ones identified by virtual screening.
Keywords
Antivirulence drugs , WAAC , Anti-infective , E. coli , Glycosyltranferases , Virtual screening
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799708
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