Author/Authors :
Jitendra A. Sattigeri، نويسنده , , Murugaiah M.S. Andappan، نويسنده , , Kaushal Kishore، نويسنده , , Srinivasan Thangathirupathy، نويسنده , , Sinduja Sundaram، نويسنده , , Shuchita Singh، نويسنده , , Suchitra Sharma، نويسنده , , Joseph A. Davis، نويسنده , , Anita Chugh، نويسنده , , Vinay S. Bansal، نويسنده ,
Abstract :
The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P2 region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure–activity relationship, and selectivity against related proteases are delineated.
