Title of article
Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors
Author/Authors
Jitendra A. Sattigeri، نويسنده , , Murugaiah M.S. Andappan، نويسنده , , Kaushal Kishore، نويسنده , , Srinivasan Thangathirupathy، نويسنده , , Sinduja Sundaram، نويسنده , , Shuchita Singh، نويسنده , , Suchitra Sharma، نويسنده , , Joseph A. Davis، نويسنده , , Anita Chugh، نويسنده , , Vinay S. Bansal، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4087
To page
4091
Abstract
The induction of conformationally restricted N-(aryl or heteroaryl)-3-azabicyclo[3.1.0]hexane derivatives at P2 region of compounds of 2-cyanopyrrolidine class was explored to develop novel DPP-IV inhibitors. The synthesis, structure–activity relationship, and selectivity against related proteases are delineated.
Keywords
Type 2 diabetes , DPP-IV inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799722
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