Author/Authors :
David J. Phillips، نويسنده , , Richard J. Davenport، نويسنده , , Thierry A. Demaude، نويسنده , , Fiona P. Galleway، نويسنده , , Mark W. Jones، نويسنده , , Laurent Knerr، نويسنده , , Benjamin G. Perry، نويسنده , , Andrew J. Ratcliffe، نويسنده ,
Abstract :
We describe a novel series of imidazopyridine substituted phenylalanines which are potent VLA-4 antagonists. A wide variety of substituents are tolerated as replacements for the pendant 3-pyridyl ring. A clear structure–activity relationship was identified around the substitution of the 3-amino-cyclobut-2-enone portion of the molecule.
Keywords :
VLA-4 , phenylalanine , Imidazopyridine , integrin
