Title of article
3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors
Author/Authors
Allan Urbach، نويسنده , , Giulio G. Muccioli، نويسنده , , Eric Stern، نويسنده , , Didier M. Lambert، نويسنده , , Jacqueline Marchand-Brynaert، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4163
To page
4167
Abstract
A series of novel 2-azetidinones (β-lactams) bearing short alkenyl chains at C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. Compound 9c (1-(4′-pentenoyl-3-(4′-pentenyl)-2-azetidinone)) featured an IC50 value of 4.5 μM and a good selectivity for FAAH versus MGL.
Keywords
Azetidinone , Enolate alkylation , FAAH inhibition , MGL inhibition
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799740
Link To Document