Title of article
Discovery of potent and cell-active allosteric dual Akt 1 and 2 inhibitors
Author/Authors
Tony Siu، نويسنده , , Jun Liang، نويسنده , , Jeannie Arruda، نويسنده , , Yiwei Li، نويسنده , , Raymond E. Jones، نويسنده , , Deborah Defeo-Jones، نويسنده , , Stanley F. Barnett، نويسنده , , Ronald G. Robinson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4186
To page
4190
Abstract
This paper describes the improvement of cell potency in a class of allosteric Akt 1 and 2 inhibitors. Key discoveries include identifying the solvent exposed region of the molecule and appending basic amines to enhance the physiochemical properties of the molecules. Findings from the structure–activity relationships are discussed.
Keywords
Akt , kinase , Cell active , Allosteric
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799745
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