Title of article
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
Author/Authors
Edite Verissimo، نويسنده , , Neil Berry، نويسنده , , Peter Gibbons، نويسنده , , M. Lurdes S. Cristiano، نويسنده , , Philip J. Rosenthal، نويسنده , , Jiri Gut، نويسنده , , Stephen A. Ward، نويسنده , , Paul M. O’Neill، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
5
From page
4210
To page
4214
Abstract
The structure-based design, chemical synthesis and in vitro activity evaluation of various falcipain inhibitors derived from 2-pyridone are reported. These compounds contain a peptidomimetic binding determinant and a Michael acceptor terminal moiety capable of deactivating the cysteine protease active site.
Keywords
malaria , Plasmodium falciparum , cysteine protease , Falcipain-2 , PeptidomimeticArticle Outline
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799750
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