Title of article
Design and optimization of potent, selective antagonists of Oxytocin
Author/Authors
Alan Brown، نويسنده , , Lindsay Brown، نويسنده , , Dave Ellis، نويسنده , , Nicholas Puhalo، نويسنده , , Chris R. Smith، نويسنده , , Olga Wallace، نويسنده , , Lesa Watson، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
4
From page
4278
To page
4281
Abstract
A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.
Keywords
Oxytocin , Antagonist , triazole
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2008
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
799763
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